Leptin beyond the lipostat: key component of blood pressure regulation.
نویسندگان
چکیده
منابع مشابه
The relationship between circulating levels of IL-18 and leptin, HsCRP, blood pressure and cardiorespiratory function in obese and lean men
ABSTRACT Introduction: Interleukin-18 (IL-18) is a proinflammatory cytokine that is produced in adipose tissue and skeletal muscle. The circulating levels of IL-18 increases in obesity and some metabolic and cardiorespiratory diseases. The aim of the present study is to investigate the relationship between circulating levels of IL-18 and leptin, high-sensitivity C-reactive protei...
متن کاملLeptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.
Leptin is a key neuroendocrine hormone regulating food intake, metabolism, and fat accumulation, and it may also affect blood pressure and contribute to hypertension through sympathetic activation in the vasculature or at the renal level. Although previous studies have shown that the distribution of leptin is significantly different between males and females, as is the risk of hypertension betw...
متن کاملرابطه نمایه توده بدن با سطوح سرمی لپتین و ارتباط این دو با فشار خون در کودکان چاق
Background: It is well recognized that an increased body weight is often associated with increased blood pressure. Moreover, leptin an adipocyte-derived hormone is strongly suggested to have an important role in pathogenesis of the obesity. We aimed to evaluate the levels of serum leptin in association with obesity and hypertension in a sample of Iranian obese children. Methods: Children from...
متن کاملThe role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models.
A little more than a decade ago, the molecular basis of the lipostat was largely unknown. At that time, many laboratories were at work attempting to clone the genes encoding the obesity, diabetes, fatty, tubby and agouti loci, with the hope that identification of these obesity genes would help shed light on the process of energy homeostasis, appetite and energy expenditure. Characterization of ...
متن کاملLipid Profile and Leptin Levels in Patients with Metabolic Syndrome
Abstract Background and Objective: Metabolic syndrome called a cluster of several metabolic disorders is associated with increased risk of cardiovascular diseases. Genetic differences in leptin receptor gene are related with the concentration and activity of leptin in that these discrepancies can influence lipid levels. We aimed to determine the association between the leptin receptor gene p...
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ورودعنوان ژورنال:
- Circulation research
دوره 116 8 شماره
صفحات -
تاریخ انتشار 2015